Wow, I'm surprised this actually got some replies. It's been up a month under the title "After all the hype, it finally happened"
Anyway, apart from the possible location of Skyrim, and the possible inclusion of dragons, we know that they are finally going to use a new engine. Remember the nostalgic Fallout 3, Morrowind, New Vegas and Oblivion game engine? Not anymore!
This could mean that we don't have to zoom in on characters facial flaws during speech anymore.