It is VERY different, I think, in that size damage actually weakens the capabilities of the sufferer, and is tied to tangible traits that exist (the size of the structure) instead of being an arbitrary invisible cushion that drags out fights because you have to stab a guy in the throat 79 times to make the 80th suddenly behave like a throat stab.
Think of it like this: if you want to brute force that thing that is as big as 8 guys, and can use as much weaponry as 8 guys, you have to do 8 size damage. And every time you do enough size damage to kill a guy, that big thing is suddenly one guy's worth of power weaker. It is basically just like fighting a bunch of soldiers of equal total size and power, that weakens as you hit it instead of staying at 100% power and thus gives you more options than "everyone shoot the same thing to give them less actions," which is basically the ONLY strategy in too many games where HP is involved.
Besides, component damage is also a (glorious) thing that can let you ignore size damage in a lot of cases, anyway. It is fun to know that you can take out dragons or other giant monsters by launching glorious, heroic
charges to just slice off the head, or wherever the mind is, or even cripple its ability to fight by taking some OTHER vital piece of it out (like mobility killing a tank), instead of HAVING to stab it in the toe 100 times so all of its blood leaks out.
Component damage lets you come up with super creative fixes to big problems, that either make battles flashy, memorable displays of ingenious gambits, or
flaming disasters that are equally memorable. WAY more fun than just focusing enemies one at a time because HP is a thing.
Another fun place for superhero inspiration is Batman: The Brave and the Bold. It is a love letter to the insane mockery of reality that was the Silver Age, and can give some great inspiration for ridiculous super-villain plans and doomsday devices, or as precedent to explain that the hero did not KILL that guy he just splattered across 3 city blocks with exploding boomerangs, he "tactically non-lethally disabled him" for the police to
/pick up.